L-Methylfolate 1000mcg - 180 Capsules | Vitamin B9 5-MTHF Folate Supplement | Made in Canada

What Is L-Methylfolate (5-MTHF)?

Folate is an essential B vitamin (vitamin B9) that plays a critical role in red blood cell formation, nutrient metabolism, and fetal development. Most folate supplements on the market use synthetic folic acid — a form the body must convert through multiple enzymatic steps before it can be used.

L-Methylfolate, also known as 5-MTHF (5-methyltetrahydrofolate), is the biologically active end-product of that conversion process. When you take 5-MTHF directly, your body can put it to work immediately — no conversion required.

Why the Form of Folate Matters

A significant portion of the population carries a variant of the MTHFR gene, which reduces the body's ability to convert folic acid into its usable form. For these individuals, supplementing with standard folic acid may be far less effective than supplementing with pre-converted 5-MTHF.

Even for those without an MTHFR variant, choosing the methylated form simply removes a conversion step — meaning more folate is available to the body, more reliably.

What Makes Herba® L-Methylfolate Different

Herba® L-Methylfolate uses folate as the calcium salt of L-5-Methyltetrahydrofolate — a highly stable, pharmaceutical-grade form of 5-MTHF. This salt form offers superior stability compared to the free acid form, helping ensure potency throughout the product's shelf life.

Each bottle provides 180 vegetable capsules — a full 6-month supply at the recommended one capsule daily dose. Third-party tested for purity, heavy metals, and microbial safety, Herba® L-Methylfolate is proudly made in Canada.

Recommended Uses

• Helps to form red blood cells.
• Helps to maintain/support the body's ability to metabolize nutrients.
• Helps to prevent folate deficiency.
• Helps to reduce the risk of neural tube defects when taken daily at least three months prior to becoming pregnant and during early pregnancy.
• Helps to support normal early fetal development (brain and spinal cord).
• Source of vitamin to support biological functions which play a key role in the maintenance of good health.

Medicinal ingredient (per capsule)

• Folate (L-5-Methyltetrahydrofolate, calcium salt) - 1 mg

Non-medicinal ingredients: Hypromellose, brown rice flour

Directions

• Adults (19 years and older): Take 1 capsule, 1 time per day.

Q. What is the difference between L-Methylfolate and folic acid?
A. Folic acid is a synthetic form of vitamin B9 that the body must convert through several enzymatic steps before it can be used. L-Methylfolate (5-MTHF) is the active, end-form of that process — meaning it's ready for the body to use directly, with no conversion required.

Q. What is the MTHFR gene mutation, and why does it matter for folate?
A. MTHFR is a gene that codes for an enzyme involved in converting folic acid into active folate. A common variant of this gene reduces that enzyme's efficiency, which can limit how much usable folate a person gets from standard folic acid supplements. Since L-Methylfolate is already in its active form, it bypasses this conversion step entirely — making it the preferred option for those with MTHFR variants.

Q. How much L-Methylfolate is in each capsule, and how long does one bottle last?
A. Each capsule delivers 1,000mcg (1 mg) of folate from L-5-Methyltetrahydrofolate, calcium salt. At the recommended dose of one capsule per day, a single bottle of 180 capsules provides a full 6-month supply.

Q. How should I take Herba® L-Methylfolate?
A. Adults 19 years and older should take 1 capsule, 1 time per day. For pre-pregnancy use, the label recommends beginning at least three months prior to becoming pregnant and continuing during early pregnancy.

Q. Is this product vegan and free from common allergens?
A. Yes. Herba® L-Methylfolate is vegan, gluten-free, and non-GMO. The capsule shell is made from hypromellose (a plant-derived material).

Q. What does "NPN" mean, and why does it matter?
A. NPN stands for Natural Product Number — a licence issued by Health Canada that confirms a natural health product has been reviewed for safety, efficacy, and quality before being sold in Canada. Herba® L-Methylfolate holds NPN 80144471, meaning it has passed Health Canada's regulatory review.

Q. What is the calcium salt form of 5-MTHF, and is it better?
A. The calcium salt form of L-5-Methyltetrahydrofolate is a stabilized version of 5-MTHF that offers improved stability during storage compared to the free acid form. This helps ensure that the potency listed on the label is maintained throughout the product's shelf life.

Q. Is Herba® L-Methylfolate third-party tested?
A. Yes. The product is third-party tested for purity, heavy metals, and microbial safety, and is manufactured following cGMP standards in a Canadian facility.