NAD+ Supplement 550mg – 60 Capsules | 4-in-1 NAD Plus Total with Nicotinamide Riboside (NR), β-NMN, Resveratrol & Quercetin | Made in Canada

Understanding NAD+ Precursors: The Dual-Pathway Advantage

Nicotinamide Adenine Dinucleotide (NAD+) is a vital coenzyme present in every cell of your body, essential for converting nutrients into cellular energy and supporting numerous biological processes. NAD+ levels naturally decline with age, which is why supplementation with precursor compounds has gained significant scientific attention.
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Herba® NAD+ Total employs a unique dual-precursor strategy by providing both Nicotinamide Riboside (NR) and β-Nicotinamide Mononucleotide (NMN). While both compounds ultimately convert to NAD+, they follow complementary pathways. NMN sits one biochemical step closer to NAD+ in the biosynthesis pathway, while NR is a smaller molecule that readily enters cells through equilibrative nucleoside transporters. Once inside cells, NR converts to NMN before becoming NAD+. By providing both precursors, our formula ensures robust support through multiple biological routes rather than relying on a single pathway.
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Why We Added Resveratrol and Quercetin

The inclusion of trans-Resveratrol (100mg) and Quercetin (50mg) transforms this from a simple precursor supplement into a comprehensive NAD+ support system. Research demonstrates that resveratrol can activate NMNAT1, an NAD+ synthetic enzyme, while also activating sirtuins—particularly SIRT1—which are NAD+-dependent enzymes that play crucial roles in cellular health. Quercetin similarly activates SIRT1 and helps maintain optimal NAD+/NADH balance by stimulating the Krebs cycle.
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Both compounds function as potent antioxidants, providing cellular protection against oxidative stress. Studies show that resveratrol and quercetin can potentiate the cell-protective effects of NAD+ precursors, creating a synergistic effect that maximizes the potential of the entire formula. This comprehensive approach addresses both NAD+ production and the activation of NAD+-dependent biological functions.
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Pharmaceutical-Grade Ingredients Made in Canada
We source pharmaceutical-grade Nicotinamide Riboside chloride and β-NMN for optimal purity and bioavailability. Our trans-Resveratrol is derived from Reynoutria japonica root, a concentrated source of this beneficial compound. The formula contains only bioavailable forms and is manufactured in Canada in a facility following current Good Manufacturing Practices (cGMP).

Recommended Uses
Helps in energy metabolism and tissue formation. NMN is a NAD+ precursor which helps to support biological functions which play a key role in the maintenance of good health.

Medicinal ingredients (per capsule):

• Nicotinamide riboside (Nicotinamide riboside chloride) - 300 mg
• NMN (Nicotinamide mononucleotide) - 100 mg
• trans-Resveratrol (Resveratrol, Reynoutria japonica - root) - 100 mg
• Quercetin (Quercetin dihydrate) - 50 mg

Non-medicinal ingredients: Hypromellose, l-leucine, rice flour

Directions:

Adults (18 years and over): Take 1-2 capsules, once daily. Take with food/meal. Ask a health care practitioner for use beyond 12 weeks.

Warnings:

Ask a health care practitioner before use if • you are pregnant or breastfeeding • you have diabetes • you are taking medications or any other health products, as resveratrol may alter their effectiveness.

Q. What's the difference between taking both NR and NMN versus just one precursor?

A. Most NAD+ supplements contain either NR or NMN alone. Herba® NAD+ Total provides both precursors because they work through complementary pathways. NR enters cells easily due to its smaller molecular size, then converts to NMN inside the cell. NMN sits one step closer to NAD+ in the biosynthesis pathway and may utilize its own cellular transporter. This dual-pathway approach ensures comprehensive NAD+ support rather than relying on a single conversion route.​

Q. Why did you include resveratrol and quercetin with the NAD+ precursors?

A. Resveratrol and quercetin create a synergistic effect by activating sirtuins (especially SIRT1), which are NAD+-dependent enzymes that require NAD+ to function. Research shows these compounds can potentiate the cellular benefits of NAD+ precursors while providing antioxidant protection. Resveratrol can also activate NMNAT1, an enzyme involved in NAD+ synthesis, while quercetin helps maintain optimal NAD+/NADH balance. Together, they maximize the effectiveness of the NR and NMN in the formula.​

Q. How do I take Herba® NAD+ Total and what's the recommended dosage?

A. Adults 18 years and over should take 1-2 capsules once daily with food or a meal. Each capsule provides 550mg of the complete 4-in-1 matrix (300mg NR, 100mg NMN, 100mg trans-Resveratrol, 50mg Quercetin). If you plan to use the supplement beyond 12 weeks, consult a healthcare practitioner.​

Q. Is this supplement vegan and free from common allergens?

A. Yes, Herba® NAD+ Total is 100% vegan, formulated with vegetable capsules and plant-based ingredients. It contains no animal-derived ingredients, is non-GMO, and gluten-free. The formula contains no dairy, soy, eggs, fish, shellfish, or nuts. Non-medicinal ingredients are limited to hypromellose (vegetable capsule), l-leucine, and rice flour.​

Q. What does the NPN number mean and why is it important?

A. NPN 80143055 is a Natural Product Number issued by Health Canada after rigorous review of the product's safety, efficacy, and quality. This eight-digit number confirms that Herba® NAD+ Total has been assessed and licensed by Health Canada's Natural and Non-prescription Health Products Directorate. Products with an NPN meet Canadian regulatory standards and can only make health claims that have been reviewed and authorized by Health Canada.​

Q. How is your formula tested for quality and purity?

A. Every batch of Herba® NAD+ Total undergoes third-party laboratory testing for purity, potency, heavy metals (lead, mercury, arsenic, cadmium), and microbial contamination. We manufacture in Canada in a facility following current Good Manufacturing Practices (cGMP), which are quality standards that ensure consistent production and control according to pharmaceutical-grade protocols. All ingredients are verified for identity and purity before formulation.

Q. Can I take this supplement if I have diabetes or am on medications?

A. You should consult a healthcare practitioner before use if you have diabetes, are taking medications, or are taking any other health products, as resveratrol may alter the effectiveness of certain medications. This is particularly important because NAD+ precursors can influence metabolic pathways. Also consult a healthcare professional if you are pregnant or breastfeeding.​

Q. What's the difference between this formula and cheaper NAD+ supplements?

A. Herba® NAD+ Total combines pharmaceutical-grade Nicotinamide Riboside chloride (the most studied form of NR) and β-NMN with trans-Resveratrol from Reynoutria japonica and Quercetin dihydrate. Many lower-cost products use only one NAD+ precursor without synergistic compounds, may contain lower-purity ingredients, or lack third-party testing verification. Our 4-in-1 formula is manufactured in Canada under cGMP standards and holds a valid Health Canada NPN, ensuring regulatory compliance and quality assurance.